Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not
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چکیده
منابع مشابه
Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero.
Two B-type cyclins, B1 and B2, have been identified in mammals. Proliferating cells express both cyclins, which bind to and activate p34(cdc2). To test whether the two B-type cyclins have distinct roles, we generated lines of transgenic mice, one lacking cyclin B1 and the other lacking cyclin B2. Cyclin B1 proved to be an essential gene; no homozygous B1-null pups were born. In contrast, nulliz...
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Patients with hypophosphatemia rickets (including DMP1 mutations) develop severe osteoarthritis (OA), although the mechanism is largely unknown. In this study, we first identified the expression of DMP1 in hypertrophic chondrocytes using immunohistochemistry (IHC) and X-gal analysis of Dmp1-knockout-lacZ-knockin heterozygous mice. Next, we characterized the OA-like phenotype in Dmp1 null mice f...
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Mice lacking all pro-opiomelanocortin (POMC)-derived peptides have been created by gene targeting of the POMC locus in embryonic stem cells. Phenotypes of the POMC null homozygous mutants include obesity, pigmentation defects, and adrenal insufficiency. Here, we report that both POMC null homozygous and heterozygous mutants also develop pituitary gland tumors, which result in their premature de...
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Transgenic liver-specific inactivation of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM1) impairs hepatic insulin clearance and causes hyperinsuline-mia, insulin resistance, elevation in hepatic and serum triglyceride levels, and visceral obesity. It also predisposes to nonalchoholic steatohepatitis (NASH) in response to a high-fat diet. To discern whether this phenotype r...
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Address: 1Department of Pharmacology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA, 2Department of Pathology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA, 3Department of Physiology & Biophysics, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA and 4Department of Pathology and Laboratory Medicine, University of Nort...
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ژورنال
عنوان ژورنال: Life Science Alliance
سال: 2020
ISSN: 2575-1077
DOI: 10.26508/lsa.201900593